Ulcerated Necrobiosis Lipoidica: A Combined Treatment Approach with Dermatosurgery and PUVA
Identifieur interne : 008F76 ( Main/Exploration ); précédent : 008F75; suivant : 008F77Ulcerated Necrobiosis Lipoidica: A Combined Treatment Approach with Dermatosurgery and PUVA
Auteurs : Erich Köstler [Allemagne] ; Uwe Wollina [Allemagne]Source :
- The International Journal of Lower Extremity Wounds [ 1534-7346 ] ; 2003-12.
English descriptors
Abstract
Ulcerated necrobiosis lipoidica is one of the differential diagnoses in leg ulcers. The diagnosis is confirmed by histopathology. The authors report on a 68-year-old female patient with a history of chronic venous insufficiency who developed a chronic leg ulcer that did not respond to good ulcer care and compression bandaging. Skin biopsies revealed necrobiosis lipoidica. The patient was recently discovered to have diabetes mellitus that was treated orally by ascarose. Phlebosurgery and mesh grafting were performed, and the patient was given pentoxyfiline, dapsone, and clofazimine, but none of these treatments was successful. Therefore, topical PUVA therapy was introduced that resulted in partial remission and stabilizing of the residual pathology. Based on these experiences, the use of surgical methods alone is questionable.
Url:
DOI: 10.1177/1534734603260680
Affiliations:
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<front><div type="abstract" xml:lang="en">Ulcerated necrobiosis lipoidica is one of the differential diagnoses in leg ulcers. The diagnosis is confirmed by histopathology. The authors report on a 68-year-old female patient with a history of chronic venous insufficiency who developed a chronic leg ulcer that did not respond to good ulcer care and compression bandaging. Skin biopsies revealed necrobiosis lipoidica. The patient was recently discovered to have diabetes mellitus that was treated orally by ascarose. Phlebosurgery and mesh grafting were performed, and the patient was given pentoxyfiline, dapsone, and clofazimine, but none of these treatments was successful. Therefore, topical PUVA therapy was introduced that resulted in partial remission and stabilizing of the residual pathology. Based on these experiences, the use of surgical methods alone is questionable.</div>
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